| Bioactivity | Mitragynine ((-)-Mitragynine) is a psychoactive compound. Mitragynine has a high affinity to μ-opioid receptors, acts at supraspinal μ- and δ-opioid receptors for its antinociceptive effects. Mitragynine can inhibit Ca2+ channel currents in neuroblastoma cells and inhibit the twitch response to electrical stimulation in guinea-pig vas deferens. Analgesic, antitussive, antidiarrheal, adrenergic, antimalarial activity[1][2]. |
| Invitro | Mitragynine (1 μM) blocks T- and L-type Ca2+ channel currents in N1E-115 neuroblastoma cells[2].Mitragynine (10 nM-1 μM) reduces KCl-induced Ca2+ influx in neuroblastoma cells[2]. |
| In Vivo | Mitragynine (300 nM-10 μM) inhibits the twitch response to electrical stimulation in guinea-pig vas deferens in a concentration-dependent manner[2].Mitragynine (3-10 μM) inhibits nicotine-induced (1 mM) contraction of guinea-pig vas deferens in a concentration-dependent manner[2].Mitragynine (1.5 mg/kg for IV, 50 mg/kg for PO, single dosage) exhibits a biphasic elimination from plasma, and the oral absorption is slow, prolonged and incomplete[3].Pharmacokinetic Parameters of Mitragynine in male Sprague-Dawley rats[3]. |
| Name | Mitragynine |
| CAS | 4098-40-2 |
| Formula | C23H30N2O4 |
| Molar Mass | 398.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hassan Z, et al. From Kratom to mitragynine and its derivatives: physiological and behavioural effects related to use, abuse, and addiction. Neurosci Biobehav Rev. 2013 Feb;37(2):138-51. [2]. Parthasarathy S, et al. Determination of mitragynine in plasma with solid-phase extraction and rapid HPLC-UV analysis, and its application to a pharmacokinetic study in rat. Anal Bioanal Chem. 2010 Jul;397(5):2023-30. [3]. Matsumoto K, et al. Inhibitory effect of mitragynine, an analgesic alkaloid from Thai herbal medicine, on neurogenic contraction of the vas deferens. Life Sci. 2005 Nov 26;78(2):187-94. |