Microtubule destabilizing agent-2_product_DataBase

Bioactivity	Microtubule destabilizing agent-2 (Compound 21) is an orally active and selective antitumor compound targeting microtubule protein. Microtubule destabilizing agent-2 destabilizes microtubule proteins and inhibits microtubule polymers. Microtubule destabilizing agent-2 arrests the G0/G1 phase in human tumor cells. Microtubule destabilizing agent-2 induces Apoptosis by activating the cascade pathway of caspases. Microtubule destabilizing agent-2 has anti-inflammatory activity, as inhibiting TNF-α and IL-6 in vitro. Microtubule destabilizing agent-2 reduces tumors growth in xenograft mice[1].
Invitro	Microtubule destabilizing agent-2 (48 h) 相较于82.46 μM (MCF-7)、31.27 μM (MDA-MB-231) 的IC50，对人白血病细胞K-562具有选择性抗增殖作用 (IC50: 3.27 μM)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Microtubule destabilizing agent-2 相关抗体:
In Vivo	Microtubule destabilizing agent-2 (20-80 mg/kg，口服， 28天) 在 K562 异种移植小鼠模型中具有中至低度抗癌效果[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
Formula	C26H26O4
Molar Mass	402.48
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Fatima, et al. 5H-benzo[c]fluorene derivative exhibits antiproliferative activity via microtubule destabilization. Bioorganic chemistry, 2024, 153:107891.

PeptideDB

Microtubule destabilizing agent-2

CAS: F: C26H26O4 W: 402.48