| Bioactivity | Mezigdomide (CC-92480), a cereblon E3 ubiquitin ligase modulating drug (CELMoD), acts as a molecular glue. Mezigdomide shows high affinity to cereblon, resulting in potent antimyeloma activity[1]. | ||||||||||||
| Invitro | Mezigdomide is the second cereblon modulator. Mezigdomide-induced loss of Aiolos and Ikaros in cultures of PBMCs resulted in the activation of T cells and increased production of IL-2 and IFN-γ. Mezigdomide is effective in CC-5013, CC-4047, and CC-220-resistant cell lines. It exerts single-agent induction of apoptosis and exhibits remarkable synergy with NSC 34521[1]. | ||||||||||||
| Name | Mezigdomide | ||||||||||||
| CAS | 2259648-80-9 | ||||||||||||
| Formula | C32H30FN5O4 | ||||||||||||
| Molar Mass | 567.61 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Mezigdomide
CAS: 2259648-80-9 F: C32H30FN5O4 W: 567.61
Mezigdomide (CC-92480), a cereblon E3 ubiquitin ligase modulating drug (CELMoD), acts as a molecular glue. Mezigdomide s
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