| Bioactivity | Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity[1]. Metyrosine is a very effective agent for blood pressure control[2]. | ||||||||||||
| Invitro | Metyrosine acts by inhibiting tyrosine hydroxylase, thus causing depletion of adrenal stores of catecholamines[2]. | ||||||||||||
| In Vivo | Metyrosine (50-200 mg/kg; i.p.) reduces carrageenan inflammation[1].Metyrosine (50-200 mg/kg; i.p.) shows antiulcerative activity is 87.7%, 93.7% and 95.5% for 50, 100 and 200 mg/kg doses of metyrosine, respectively[1]. Animal Model: | ||||||||||||
| Name | Metyrosine | ||||||||||||
| CAS | 672-87-7 | ||||||||||||
| Formula | C10H13NO3 | ||||||||||||
| Molar Mass | 195.22 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Albayrak A, Polat B, Cadirci E, et al. Gastric anti-ulcerative and anti-inflammatory activity of metyrosine in rats. Pharmacol Rep. 2010;62(1):113‐119. [2]. Garg MK, et al. Medical management of pheochromocytoma: Role of the endocrinologist. Indian J Endocrinol Metab. 2011;15 Suppl 4(Suppl4):S329‐S336. |