| Bioactivity | Methoprene, an insect juvenile growth hormone mimic, is a growth-regulating insecticide that manifests its toxicity to target organisms by acting as a juvenile hormone agonist[1][2]. | ||||||||||||
| Invitro | Methoprene reduces the growth rate of daphnids with evidence of only a single concentration-response line, having a threshold of 12.6 nM. Molt frequency is reduced by methoprene in a concentration-dependent manner, with a response curve corresponding to a 2-segmented line and thresholds at 4.2 and 0.21 nM. An endpoint related to reproductive maturation, the time of first brood deposition, is also affected by methoprene, with a clear concentration-dependent response and a NOEC of 32 nM. Methoprene reduces fecundity according to a 2-segmented line, with thresholds of 24 and < or =0.18 nM. Methoprene elicits significant toxicity to endocrine-related processes in the 5-50 nM concentration range[1]. | ||||||||||||
| Name | Methoprene | ||||||||||||
| CAS | 40596-69-8 | ||||||||||||
| Formula | C19H34O3 | ||||||||||||
| Molar Mass | 310.47 | ||||||||||||
| Appearance | Liquid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Olmstead AW, LeBlanc GL. Low exposure concentration effects of methoprene on endocrine-regulated processes in the crustacean Daphnia magna. Toxicol Sci. 2001;62(2):268-273. [2]. Monteiro JP, et al. Toxicity of methoprene as assessed by the use of a model microorganism. Toxicol In Vitro. 2005;19(7):951-956. |