| Bioactivity | Methocarbamol is an orally active central muscle relaxant and blocks muscular Nav1.4 channel. Methocarbamol reversibly affects voltage dependence of inactivation of Nav1.4 channel. Methocarbamol has the potential for muscle spasms and pain syndromes research[1][2][3]. | ||||||||||||
| Invitro | Methocarbamol (2 mM; for 20 min) significantly increases the decay times of the EPCs and those of the EPPs induced by the phrenic nerve stimulation[3]. Methocarbamol has no effect on Nav1.7 currents[3]. | ||||||||||||
| In Vivo | Methocarbamol (200 mg/kg; ip) has Muscle relaxant activity of 88.96%[3]. Animal Model: | ||||||||||||
| Name | Methocarbamol | ||||||||||||
| CAS | 532-03-6 | ||||||||||||
| Formula | C11H15NO5 | ||||||||||||
| Molar Mass | 241.24 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Bruce, R.B., L.B. Turnbull, and J.H. Newman, Metabolism of methocarbamol in the rat, dog, and human. J Pharm Sci, 1971. 60(1): p. 104-6. [2]. Sica, D.A., et al., Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals. Eur J Clin Pharmacol, 1990. 39(2): p. 193-4. [3]. Yaxin Zhang, et al. Methocarbamol blocks muscular Na v 1.4 channels and decreases isometric force of mouse muscles. Muscle Nerve. 2020 Oct 11. |
Methocarbamol
CAS: 532-03-6 F: C11H15NO5 W: 241.24
Methocarbamol is an orally active central muscle relaxant and blocks muscular Nav1.4 channel. Methocarbamol reversibly a
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.