| Bioactivity | Methapyrilene is a histamine antagonist, a pyridine chemical with anticholinergic activity. Methapyrilene can cause target organ-specific epigenetic alterations, such as a decrease in DNA methylation levels. Methapyrilene induces hepatocellular carcinoma in rats[1][2]. |
| Invitro | Methapyrilene (650 μM, 72 h) decreases the transcriptional level of transferrin and is accompanied by a decrease in transferrin protein levels in HepRG cells[1]. |
| In Vivo | Methapyrilene (gavage with water (vehicle), 50 or 150 mg/kg, daily, 3 days) can induce hepatotoxicity and lead to periportal hepatic necrosis in rats[2]. Animal Model: |
| Name | Methapyrilene |
| CAS | 91-80-5 |
| Formula | C14H19N3S |
| Molar Mass | 261.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Volodymyr Tryndyak, et al. Effect of aflatoxin B1, benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. [2]. Andrew Craig, et al. Systems toxicology: integrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the rat. J Proteome Res. 2006 Jul;5(7):1586-60 |