| Bioactivity | Melitracen (Melitracene) is an orally active tricyclic antidepressant and it is also a bipolar thymoleptic with activating properties. Melitracen inhibits 3H-5-HT and 14H-5-HT with IC50s of 670 nM and 5500 nM, respectively. Melitracen can be used for the research of depression and anxiety[1][2]. |
| Target | IC50: 670 nM (3H-5-HT), 5500 nM (14H-5-HT) |
| Invitro | Melitracen (0-10 μM; 10 min) inhibits 3H-5-HT in synaptosomes and 14H-5-HT in blood platelets[2]. Cell Viability Assay[2] Cell Line: |
| In Vivo | Melitracen (10-90 mg/kg; p.o. once daily for 3 months) affects behavior, weight and growth of rats[1]. Animal Model: |
| Name | Melitracen |
| CAS | 5118-29-6 |
| Formula | C21H25N |
| Molar Mass | 291.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shimamoto K, et al. Relationship between the restriction of food intake and Melitracen, an antidepressant, in the rat. Acta Sch Med Univ Kioto. 1967 Jul;40(1):25-37. [2]. Hyttel J. Effect of a specific 5-HT uptake inhibitor, citalopram (Lu 10-171), on 3H-5-HT uptake in rat brain synaptosomes in vitro. Psychopharmacology (Berl). 1978 Dec 15;60(1):13-8. doi: 10.1007/BF00429172. PMID: 104340. |