| Bioactivity | Meclonazepam (Ro 11-3128) is a benzodiazepine compound with anxiolytic effect[1]. Meclonazepam is active against immature S. mansoni. Meclonazepam (30 μM) eliminates 100% of immature parasites. Meclonazepam has a anti-schistosomal effect[2]. |
| Invitro | Meclonazepam causes initially a massive spastic paralysis of immature S. mansoni[2]. |
| In Vivo | Meclonazepam (0.1-5.6 mg/kg) exhibits anxiolytic effect in gerbils[1].Meclonazepam (40 and 80 mg/kg) Has highly significant effect on the immature schistosomes[2]. Animal Model: |
| Name | Meclonazepam |
| CAS | 58662-84-3 |
| Formula | C16H12ClN3O3 |
| Molar Mass | 329.74 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. T U Järbe, et al. Cueing effects of anxiolytic benzodiazepines (DZP and Ro 11-3128): stereospecificity and antagonism by the convulsant benzodiazepine Ro 5-3663. Psychopharmacology (Berl). 1988;94(4):501-6. [2]. L Pica-Mattoccia, et al. Praziquantel and the benzodiazepine Ro 11-3128 do not compete for the same binding sites in schistosomes. Parasitology. 2008 Jan;135(Pt 1):47-54. |
Meclonazepam
CAS: 58662-84-3 F: C16H12ClN3O3 W: 329.74
Meclonazepam (Ro 11-3128) is a benzodiazepine compound with anxiolytic effect. Meclonazepam is active against immature S
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