| Bioactivity | Mebendazole is a highly effective, broad-spectrum antihelmintic against nematode infestations. Mebendazole also exhibits inhibitory effect against glioblastoma multiforme (GBM), inhibits Hedgehog pathway and tubulin polymerization. Mebendazole is orally active and can cross CNS penetration[1][2][3]. | ||||||||||||
| Invitro | Mebendazole (1 nM-0.1 mM; 72 h) shows inhibition of GL261 mouse glioma cells with IC value of 0.24 μM[1]. Mebendazole (0.1 μM and 1 μM; 24 h) disrupts microtubule polymerization and microtubule structure in 060919 glioblastoma multiforme (GBM) cells[1].Mebendazole (10 nM-10 μM; 48 h) inhibits Hh signaling and reduces the expression of downstream Hh pathway effectors, by decreasing Gli1 transcript and protein expression in tumor tissues. Mebendazole inhibits Gli1 expression with an IC50 value of 516 nM[2].Mebendazole (10 nM-10 μM; 48 h) prevents the formation of the primary cilium, and decreases the proliferation and survival of human medulloblastoma cells with constitutive Hh activation[2].A combination of mebendazole and Vismodegib (HY-10440) achieved additive inhibition of canonical Hh signaling[2].Mebendazole has effectively treated CNS echinococcosis in numerous clinical settings before, indicating significant CNS penetration property[3]. Immunofluorescence[1] Cell Line: | ||||||||||||
| Name | Mebendazole | ||||||||||||
| CAS | 31431-39-7 | ||||||||||||
| Formula | C16H13N3O3 | ||||||||||||
| Molar Mass | 295.29 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Mebendazole
CAS: 31431-39-7 F: C16H13N3O3 W: 295.29
Mebendazole is a highly effective, broad-spectrum antihelmintic against nematode infestations. Mebendazole also exhibits
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