| Bioactivity | MeIQx-d3 is the deuterium labeled MeIQx (HY-W355129)[1]. MeIQx is a heterocyclic amine (HAs) compound and a dietary aromatic amine, which can bind covalently to hemoglobin. MeIQx is a mutagenic compound that induces liver tumors[2]. |
| Invitro | 氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。MeIQx (0.47 mM；0-120 分钟) 与小鼠血红蛋白共价结合，并被小鼠微粒体激活为代谢物[2]。 |
| In Vivo | MeIQx (2.0-200 mg/kg；腹腔注射) 在雄性 Swiss Webster 小鼠中，以剂量依赖性方式与血红蛋白共价结合[2]。 |
| Name | MeIQx-d3 |
| CAS | 122457-31-2 |
| Formula | C11H8D3N5 |
| Molar Mass | 216.26 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Lynch AM, et, al. The measurement of MeIQx adducts with mouse haemoglobin in vitro and in vivo: implications for human dosimetry. Carcinogenesis. 1991 Jun;12(6):1067-72. |