| Bioactivity | Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca2+] and secretion. Maresin 1 possesses anti-inflammatory activity[1][2][3]. |
| Invitro | Maresin 1 (MaR1, 300 nM) reduces neutrophil migration and reactive oxygen species production, besides decreasing IL-1b, TNF-a, IL-6, and INF-g production[3]. Cell Viability Assay[3] Cell Line: |
| In Vivo | Maresin 1 (MaR1) dose-dependently inhibits TRPV1 currents in neurons, blocks capsaicin (100 nM)-induced inward currents (IC50=0.49 nM), and reduces both inflammation- and chemotherapy-induced neuropathic pain in mice[2].Maresin 1 (MaR1, 0.1, 0.3, and 1 μg/animal, e.v.) protects mice against acute DSS-induced colitis. Maresin 1 (0.3, and 1 μg/animal, e.v.) treatment markedly reduces macroscopic damage in the acute protocol of DSS-induced colitis[3]. Animal Model: |
| Name | Maresin 1 |
| CAS | 1268720-28-0 |
| Formula | C22H32O4 |
| Molar Mass | 360.49 |
| Appearance | Liquid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Solution, -20°C, 2 years |
| Reference | [1]. Markus V Olsen, et al. Maresin 1, a Specialized Proresolving Mediator, Stimulates Intracellular [Ca 2+ ] and Secretion in Conjunctival Goblet Cells. J Cell Physiol. 2020 Jun 8. [2]. Macrophage Proresolving Mediator Maresin 1 Stimulates Tissue Regeneration and Controls Pain [3]. Rodrigo Marcon, et al. Maresin 1, a Proresolving Lipid Mediator Derived From omega-3 Polyunsaturated Fatty Acids, Exerts Protective Actions in Murine Models of Colitis. J Immunol. 2013 Oct 15;191(8):4288-98. |