| Bioactivity | Manzamine A, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A has antimalarial and anticancer activities. Manzamine A also shows potent activity against HSV-1[1][2][3][4]. |
| Invitro | Manzamine A (5-50 µM, 18 h) decreases tau phosphorylation, measured with ELISA[1].Manzamine A (10 µM) inhibits yeast S. cerevisiae growth by 30%[2].Manzamine A displays a few enlarged vacuoles in yeast[2].Manzamine A (2.5-10 µM, 24 h) increases acidity in pancreatic cancer cells and non-malignant Vero cells[2].Manzamine A (1 µM, 24 h) inhibits HSV-1 infection in SIRC cells[4].Manzamine A shows antimalarial activity with an IC50 of 8.0 nM (D6 clone) and 11 nM (W2 clone)[5]. Cell Viability Assay[4] Cell Line: |
| Name | Manzamine A |
| CAS | 104196-68-1 |
| Formula | C36H44N4O |
| Molar Mass | 548.76 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |