| Bioactivity | Malabaricone B, a naturally occurring plant phenolic, is an orally active α-glucosidase inhibitor with an IC50 of 63.7 µM. Malabaricone B has anticancer, antimicrobial, anti-oxidation and antidiabetic activities[1][2][3]. |
| Invitro | Malabaricone B shows selective toxicity to human lung cancer (A549), malignant melanoma (A375) and T cell leukemia (Jurkat) cell lines, without showing toxicity to human normal intestinal (INT407), human kidney (HEK293) and lung fibroblast (WI-38) cells. Among the chosen cancer cell lines, Malabaricone B shows maximum cytotoxicity to the A549 cells (IC50 = 8.1 μM), which is significantly better than that of curcumin (IC50 = 26.7 μM)[1]. The Malabaricone B-induced apoptosis is mediated by an increase in the intracellular reactive oxygen species (ROS). Malabaricone B (2.5, 5, 10 and 20 µM) increases the BAX level while simultaneously decreasing the BCL-2 and BCL-XL levels in the A549 cells, triggering the mitochondrial apoptotic pathway as revealed from the release of cytochrome c, and the activation of caspase-9 and caspase-3[1].Malabaricone B exhibits a good level of antimicrobial activity when tested against avariety of microorganisms, including Staphylococcus aureus and Candida albicans[2]. |
| Name | Malabaricone B |
| CAS | 63335-24-0 |
| Formula | C21H26O4 |
| Molar Mass | 342.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
Malabaricone B
CAS: 63335-24-0 F: C21H26O4 W: 342.43
Malabaricone B, a naturally occurring plant phenolic, is an orally active α-glucosidase inhibitor with an IC50 of 63.7
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