| Bioactivity | MPP dihydrochloride is a potent and selective ER (estrogen receptor) modulator. MPP dihydrochloride induces significant apoptosis in the endometrial cancer and oLE cell lines. MPP dihydrochloride reverses the positive effects of beta-estradiol. MPP dihydrochloride has mixed agonist/antagonist action on murine uterine ERalpha in vivo[1][2][3]. |
| Invitro | MPP (1, 5, 10, 25, 50 and 100 µM; 24 h) decreases cell viability with an IC50 value of 20.01 µM in RL95-2 cells[1].MPP dihydrochloride shows antiproliferative activity at a concentration of 10 μM in RL95-2 cells[1].MPP dihydrochloride (20 µM; 24 h) reduces the phosphorylation of ERα, while it does not alter the phosphorylation of Akt. MPP dihydrochloride reduces the ratio of p-ERα/ERα[1]. Cell Viability Assay[1] Cell Line: |
| Name | MPP dihydrochloride |
| CAS | 911295-24-4 |
| Formula | C29H33Cl2N3O3 |
| Molar Mass | 542.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
MPP dihydrochloride
CAS: 911295-24-4 F: C29H33Cl2N3O3 W: 542.50
MPP dihydrochloride is a potent and selective ER (estrogen receptor) modulator. MPP dihydrochloride induces significant
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