| Bioactivity | MLS0315771 is a potent and biologically active competitive phosphomannose isomerase (MPI) inhibitor, with an IC50 ~1 μM and a Ki of 1.4 μM. | ||||||||||||
| Target | IC50: ~1 μM (MPI). | ||||||||||||
| Invitro | MLS0315771 increases mannose flux toward glycosylation.MLS0315771 toxicity at higher concentrations is an off-target effect. MLS0315771 is toxic to the zebrafish embryos above 2 μM. At 8-10 μM, ~50% embryos appeare sick within 20 min, and most of them die by 30-60 min[1]. | ||||||||||||
| Name | MLS0315771 | ||||||||||||
| CAS | 727664-91-7 | ||||||||||||
| Formula | C15H12FNOS | ||||||||||||
| Molar Mass | 273.33 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Sharma V, et al. Phosphomannose isomerase inhibitors improve N-glycosylation in selected phosphomannomutase-deficient fibroblasts. J Biol Chem. 2011 Nov 11;286(45):39431-8. |
MLS0315771
CAS: 727664-91-7 F: C15H12FNOS W: 273.33
MLS0315771 is a potent and biologically active competitive phosphomannose isomerase (MPI) inhibitor, with an IC50 ~1 μM
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