| Bioactivity | ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC50=6.24 nM). ML401 shows good stability and no toxicity[1]. | ||||||||||||
| Target | IC50: 1.03 nM (EBI2) | ||||||||||||
| Invitro | ML401 shows no toxicity (>50 μM) towards immortalized Fa2-N4 human hepatocytes and non-cytotoxic in MTT in both LnCap and IMR-32 cells (>50 μM)[1]. | ||||||||||||
| In Vivo | ML401 shows very good stability in both human plasma and mouse plasma[1]. | ||||||||||||
| Name | ML401 | ||||||||||||
| CAS | 1597489-14-9 | ||||||||||||
| Formula | C20H20BrClN2O | ||||||||||||
| Molar Mass | 419.74 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Ardecky R, et al. Functional Antagonists of EBI-2. Probe Reports from the NIH Molecular Libraries Program [Internet]. |
ML401
CAS: 1597489-14-9 F: C20H20BrClN2O W: 419.74
ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM. ML401 displ
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