ML252 hydrochloride_product_DataBase

Bioactivity	ML252 hydrochloride is a selective inhibitor of KCNQ2 (Kv7.2) channel with IC50s of 69 nM, 2.92 μM, 0.12 μM and 0.20 μM for KCNQ2, KCNQ1 (Kv7.1), KCNQ2/Q3 and KCNQ4, respectively. ML252 hydrochloride also inhibits Cytochrome P450 with IC50s of 6.1 nM (CYP1A2), 18.9 nM (CYP2C9), 3.9 nM (CYP3A4), 19.9 nM (CYP2D6), respectively. ML252 hydrochloride shows highly brain penetrant [1][2].
Invitro	ML252 (1 μM；0-48 h) hydrochloride 在大鼠肝脏小体中的内在清除率和随后预测的肝脏清除率分别为 1720 mL/min/kg 和 67.3 mL/min/kg[1]。ML252 (0.1-0 μM) hydrochloride 在 0.3 μM 开始抑制 CHO-KCNQ2 细胞系的 KCNQ2 电流，在 1 μM 时，完全抑制电流[1]。ML252 (30 μM; 48 h) hydrochloride 对 CHO 细胞无急性毒性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> ML252 hydrochloride 相关抗体:
In Vivo	ML252 (10 mg/kg，3 mg/mL；腹腔注射；单剂量；1 h 后测定) hydrochloride 在大鼠模型中的 B:P 比值为1.9，大脑绝对水平为 672 nM[1]。ML252 hydrochloride 具有不适合口服的代谢稳定性[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	2309887-61-2
Formula	C20H25ClN2O
Molar Mass	344.88
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Yu H, et al. Identification of a novel, small molecule inhibitor of KCNQ2 channels. 2011 Oct 28 [updated 2013 Feb 25]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. [2]. Cheung YY, et al. Discovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K(v)7.2 (KCNQ2) channel pharmacology: identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a potent, brain penetrant K(v)7.2 channel inhibitor. J Med Chem. 2012 Aug 9;55(15):6975-9.

PeptideDB

ML252 hydrochloride

CAS: 2309887-61-2 F: C20H25ClN2O W: 344.88