| Bioactivity | MHI-148 is a near-infrared heptamethine cyanine dye with tumor-targeting properties for cancer detection, diagnosis and treatment. MHI-148 is immediately taken up and accumulated by lysosomes and mitochondria of tumor cells, but not in lysosomes and mitochondria of normal cells[1]. | |||||||||
| Invitro | MHI-148 (10 µM, 1 h) is significantly more absorbed in HT-29 colon carcinoma cells than in normal NIH3T3 fibroblasts and has tumor imaging and targeting properties[1]. MHI-148 (0-1.5 µM, 3 days) causes only negligible toxicity in HT-29 and NIH3T3 cells[1]. | |||||||||
| Name | MHI-148 | |||||||||
| CAS | 172971-76-5 | |||||||||
| Formula | C42H52BrClN2O4 | |||||||||
| Molar Mass | 764.23 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
|
|||||||||
| Reference | [1]. Athira Raveendran, et al. Heptamethine Cyanine Dye MHI-148-Mediated Drug Delivery System to Enhance the Anticancer Efficiency of Paclitaxel. Int J Nanomedicine. 2021 Oct 21;16:7169-7180. |
MHI-148
CAS: 172971-76-5 F: C42H52BrClN2O4 W: 764.23
MHI-148 is a near-infrared heptamethine cyanine dye with tumor-targeting properties for cancer detection, diagnosis and
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.