Lisuride maleate_product_DataBase

Bioactivity	Lisuride (maleate) is a potent agonist of dopamine with a probably direct action on dopaminergic receptors. Lisuride (maleate) is an ergot derivative. Lisuride (maleate) releases the premenstrual mastalgia without significant side effects[1][2].
In Vivo	Lisuride (maleate) (0.78 and 3.13 mg/kg; i.p.; p.o.) is 3-4 times more potent on i.p. than on p.o. [2].Lisuride (maleate) (0.78-3.13 mg/kg; i.p.) antagonizes the motor depression and hypothermia induced by reserpine[2].Lisuride (maleate) (0.78-3.13 mg/kg; i.p.) is about as effective as apomorphine and D-amphetamine and causes significant hypothermia measured after dosages as low as 0.10 mg/kg i.p.[2]. Animal Model:
Name	Lisuride maleate
CAS	19875-60-6
Formula	C24H30N4O5
Molar Mass	454.52
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reference	[1]. Kaleli S, et al. Symptomatic treatment of premenstrual mastalgia in premenopausal women with lisuride maleate: a double-blind placebo-controlled randomized study. Fertil Steril. 2001;75(4):718-723. [2]. Horowski R, et al. Direct dopaminergic action of lisuride hydrogen maleate, an ergot derivative, in mice. Eur J Pharmacol. 1976;36(2):373-383.

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