| Bioactivity | Licopyranocoumarin is an isoflavonoid that shows CYP3A4 inhibitory activity with an IC50 of 32 μM. Licopyranocoumarin has potent neuroprotective activities[1]. |
| Invitro | Licopyranocoumarin（0.3-3 μM；48 小时）显着阻断 MPP+ 诱导的神经元 PC12D 细胞死亡和线粒体膜电位消失，这是由 JNK[1] 介导的。Licopyranocoumarin（0.3-3 μM；36 小时）通过抑制活性氧 (ROS) 的生成来抑制 MPP+ 诱导的 JNK 活化，从而抑制 MPP+ 诱导的神经元 PC12D 细胞死亡[1]。 Cell Viability Assay[1] Cell Line: |
| Name | Licopyranocoumarin |
| CAS | 117038-80-9 |
| Formula | C21H20O7 |
| Molar Mass | 384.38 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Takahiro Fujimaki, et al. Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson's disease. PLoS One. 2014 Jun 24;9(6):e100395. [2]. Sachiko Tsukamoto, et al. CYP3A4 inhibitors isolated from Licorice. Biol Pharm Bull. 2005 Oct;28(10):2000-2. |
Licopyranocoumarin
CAS: 117038-80-9 F: C21H20O7 W: 384.38
Licopyranocoumarin is an isoflavonoid that shows CYP3A4 inhibitory activity with an IC50 of 32 μM. Licopyranocoumarin h
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