Lenperone hydrochloride_product_DataBase

Bioactivity	Lenperone hydrochloride (AHR 2277) is an antipsychotic compound and a dopamine antagonist. Lenperone hydrochloride reduces gastroesophageal sphincter pressure of healthy dogs. Lenperone hydrochloride can be used for neurological disease research[1][2].
In Vivo	Lenperone hydrochloride (0.16 和 0.44 mg/kg；肌内注射；一次) 降低健康犬的平均值胃食管括约肌压力 (GESP)[1]。Lenperone hydrochloride (0.5，1.0 和 2.0 mg/kg；皮下注射) 在脑损伤大鼠中显示抗精神疾病的作用，诱导剂量依赖的镇静状态并减少双侧间质核、终纹[2]。 Animal Model:
Name	Lenperone hydrochloride
CAS	24677-86-9
Formula	C22H24ClF2NO2
Molar Mass	407.88
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Johnson SE, et al. Effect of lenperone hydrochloride on gastroesophageal sphincter pressure in healthy dogs. Can J Vet Res. 1989 Apr;53(2):248-50. [2]. Costall B, Naylor RJ. Mesolimbic involvement with behavioural effects indicating antipsychotic activity. Eur J Pharmacol. 1974 Jun;27(1):46-58.

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