| Bioactivity | Lenalidomide (sodium), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (sodium) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (sodium) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells[1][2]. |
| Name | Lenalidomide sodium |
| Formula | C13H13N3NaO3 |
| Molar Mass | 282.25 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jan Krönke, et, al. Lenalidomide induces degradation of IKZF1 and IKZF3. Oncoimmunology. 2014, 3,7. [2]. Venumadhav Kotla, et, al. Mechanism of action of lenalidomide in hematological malignancies. J Hematol Oncol. 2009, 2, 36. |
Lenalidomide sodium
CAS: F: C13H13N3NaO3 W: 282.25
Lenalidomide (sodium), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodul
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