| Bioactivity | Lenaldekar (LDK) inhibits human and murine T-cell expansiomn. Lenaldekar inhibits autoimmune T cell response. Lenaldekar also induces cancer cell apoptosis. Lenaldekar can be used for T-cell mediated autoimmune diseases research[1][2]. |
| Invitro | Lenaldekar (4 天) 以剂量依赖性方式抑制 CD3+ T 细胞增殖，IC50 为 3 μM[1]。Lenaldekar (3 μM，4 天) 可降低记忆 T 细胞对流感抗原 H3 的反应[1]。Lenaldekar (48 小时) 在 Jurkat T-ALL 细胞中表现出细胞毒性，IC50s 为 0.8 μM，并诱导细胞凋亡 (1 μM)[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Lenaldekar 相关抗体: |
| In Vivo | Lenaldekar (每天 40 mg/kg，腹腔注射) 可抑制致脑炎 PLP139-151 肽致敏的小鼠实验性自身免疫性脑脊髓炎 (EAE) 复发[1]。Lenaldekar (16 mg/kg，腹腔注射，每日两次) 可抑制 T 细胞急性淋巴细胞白血病 (T-ALL) 小鼠异种移植模型中的肿瘤进展[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 418800-15-4 |
| Formula | C18H14N4 |
| Molar Mass | 286.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Cusick MF, et al. Human T cell expansion and experimental autoimmune encephalomyelitis inhibited by Lenaldekar, a small molecule discovered in a zebrafish screen. J Neuroimmunol. 2012 Mar;244(1-2):35-44. [2]. Ridges S, et al, et al. Zebrafish screen identifies novel compound with selective toxicity against leukemia. Blood. 2012 Jun 14;119(24):5621-31. |