PeptideDB

LY518674

CAS: 425671-29-0 F: C23H27N3O4 W: 409.48

LY518674 is a potent, selective PPARα antagonist, with an EC50 of42 nM for human PPARα. LY518674 reduces triglycerides
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This product is for research use only, not for human use. We do not sell to patients.

Bioactivity LY518674 is a potent, selective PPARα antagonist, with an EC50 of 42 nM for human PPARα. LY518674 reduces triglycerides in and increased HDL-C and is used for the treatment of atherosclerosis[1][2][3].
Target EC50: 42 nM (human PPARα)
In Vivo LY518674 reduces triglycerides and increased HDL-C in vivo[2].LY518674 substantially increases apolipoprotein A-I (apoA-I) turnover without major impact on steady-state levels of apoA-I or high-density lipoprotein-cholesterol (HDL-C) [3].
Name LY518674
CAS 425671-29-0
Formula C23H27N3O4
Molar Mass 409.48
Appearance Solid
Transport Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Reference [1]. Bravo Y, et al. Identification of the first potent, selective and bioavailable PPARα antagonist. Bioorg Med Chem Lett. 2014 May 15;24(10):2267-72. [2]. Nissen SE, et al. Effects of a potent and selective PPAR-alpha agonist in patients with atherogenic dyslipidemia or hypercholesterolemia: two randomized controlled trials. JAMA. 2007 Mar 28;297(12):1362-73. [3]. Khera AV, et al. Potent peroxisome proliferator-activated receptor-α agonist treatment increases cholesterol efflux capacity in humans with the metabolic syndrome. Eur Heart J. 2015 Nov 14;36(43):3020-2.