| Bioactivity | LMD-009 is a selective CCR8 nonpeptide agonist. LMD-009 mediates chemotaxis, inositol phosphate accumulation, and calcium release in high potencies with EC50s from 11 to 87 nM[1]. | ||||||||||||
| Invitro | LMD-009 (0-20 nM; 90 min) stimulates inositol phosphate accumulation in COS-7 cells expressing the human CCR8 receptor[1].LMD-009 (0-100 nM; 1 h) mediates calcium release in Chinese hamster ovary cells[1].LMD-009 (0.1 nM-100 μM; 40 min) induces L1.2 cells migration[1].LMD-009 (0-10 μM; 90 min) exhibits different molecular interaction with CCR8 mutations in COS-7 cells[1].LMD-009 (0-10 nM; 90 min) exhibits no antagonist activity to other human chemokine receptors[1]. Cell Viability Assay[1] Cell Line: | ||||||||||||
| Name | LMD-009 | ||||||||||||
| CAS | 950195-51-4 | ||||||||||||
| Formula | C29H33N3O3 | ||||||||||||
| Molar Mass | 471.59 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Jensen PC, et al. Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8. Mol Pharmacol. 2007 Aug;72(2):327-40. |