LE 28_product_DataBase

Bioactivity	LE 28 is a selective and activity-dependent legumain probe. LE 28 becomes fluorescent only upon binding active legumain. LE 28 can be used for research of cancers and inflammatory diseases[1].
Invitro	LE 28 (0-5 μM, 1 h) 可以通过裂解和荧光 SDS-PAGE 标记法检测 RAW 细胞裂解物中的 legumain[1]。LE 28 (1 μM, 5 h) 在 RAW 细胞中与 Lysotracker 共定位较好[1]。
In Vivo	LE 28 (2 mg/kg, i.v.) 在小鼠肾脏中产生特异性信号[1]。LE 28 (2 mg/kg, i.v.) 在 HCT-116 异种移植肿瘤模型中 30 分钟时在肿瘤周围检测到信号，7 小时后肿瘤与正常组织之间的信噪比达到最大[1]。 Animal Model:
Name	LE 28
CAS	1416080-97-1
Formula	C102H111N10O21S3+
Molar Mass	1909.22
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Edgington LE, et al. Functional imaging of legumain in cancer using a new quenched activity-based probe. J Am Chem Soc. 2013 Jan 9;135(1):174-82.

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