| Bioactivity | L-NIL hydrochloride is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for mouse inducible NOS[1][2][3]. |
| Target | IC50: 3.3 μM (mouse inducible NO synthase), 92 μM (rat brain constitutive NO synthase). |
| Invitro | L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS and the rat brain constitutive NOS (rcNOS) and is considerably more potent for mouse inducible NOS. The IC50 values for L-NIL with mouse inducible NOS and rcNOS are 3.3 and 92 pM, respectively, indicating that L-NIL is 28-fold more selective for mouse inducible NOS. In addition, L-NIL has approximately 6-fold greater potency for mouse inducible NOS than either L-NMA or L-NNA[3]. |
| In Vivo | L-NIL (10 and 30 mg/kg, IP) prevents the inflammation, oxidative stress and autophagy induced by renal IR in mice[1]. Animal Model: |
| Name | L-NIL hydrochloride |
| CAS | 150403-89-7 |
| Formula | C8H18ClN3O2 |
| Molar Mass | 223.70 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Consuelo Pasten, et al. l-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in mice. Am J Physiol Renal Physiol. 2019 Apr 1;316(4):F624-F634. [2]. Sharon Angela Tanuseputero, et al. Intravenous Arginine Administration Downregulates NLRP3 Inflammasome Activity and Attenuates Acute Kidney Injury in Mice with Polymicrobial Sepsis. Mediators Inflamm. 2020 May 11;2020:3201635. [3]. Moore WM, et al. L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase. J Med Chem. 1994 Nov 11;37(23):3886-8. |