| Bioactivity | L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2]. | ||||||||||||
| Invitro | L-Glutamine is important as a precursor for peptide and protein synthesis, amino sugar synthesis, purine and pyrimidine and thus nucleic acid and nucleotide synthesis, and also provides a source of carbons for oxidation in some cells. L-Glutamine is the most abundant extracellular amino acid in vivo (0.7 mM compared to an approximate L-glutamate concentration of 20 µM)[1]. In BRIN-BD11 cells, culture for 24 h with 10 mM L-Glutamine compared with 1 mM resulted in substantial changes in gene expression with 148 genes upregulated more than 1.8-fold, and 18 downregulated more than 1.8-fold, including many genes involved in cellular signaling, metabolism, gene regulation, and the insulin-secretory response. L-Glutamine increases the activity of the Ca2+ regulated phosphatase calcineurin and the transcription factor Pdx1[2]. | ||||||||||||
| Name | L-Glutamine | ||||||||||||
| CAS | 56-85-9 | ||||||||||||
| Formula | C5H10N2O3 | ||||||||||||
| Molar Mass | 146.14 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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