| Bioactivity | L-689560 is a potent N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. L-689560 is widely used as a radiolabeled ligand in binding studies and used for study the roles of NMDA receptors in normal neurological processes as well as in diseases[1][2]. | ||||||||||||
| Invitro | L-689560 is a 2-carboxytetrahydroquinoline antagonist[2]. | ||||||||||||
| In Vivo | L-689560 (1 mg/kg, ip) significantly reduces the neuroprotective effect of glycine after glycine receptors and the channel activity of NMDA receptors (NMDARs) are suppressed. L-689560 blocks glycine-induced increase of Akt phosphorylation in the MCAO model[1] Animal Model: | ||||||||||||
| Name | L-689560 | ||||||||||||
| CAS | 139051-78-8 | ||||||||||||
| Formula | C17H15Cl2N3O3 | ||||||||||||
| Molar Mass | 380.23 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Juan Chen, et al. A non-ionotropic activity of NMDA receptors contributes to glycine-induced neuroprotection in cerebral ischemia-reperfusion injury. 15 June 2017 [2]. Kvist T, et al. Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. J Biol Chem. 2013 Nov 15;288(46):33124-35. |
L-689560
CAS: 139051-78-8 F: C17H15Cl2N3O3 W: 380.23
L-689560 is a potent N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. L-689560 is wide
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