| Bioactivity | Kynuramine, an endogenously occurring amine, is a fluorescent substrate and probe of plasma amine oxidase[1][2]. |
| Invitro | Kynuramine 在体外抑制突触前和突触后 α-肾上腺素受体[2]。Kynuramine 已被证明是狗脑动脉血清素受体的部分激动剂[2]。Kynuramine (20 μg/mL) 经常导致回肠轻微收缩，但未能改变胆碱能刺激的抽搐反应[2]。 |
| In Vivo | Kynuramine (0.064、0.32、1.6 或 8 μg；脑室内；单剂量) 可能在调节女性性行为中发挥生理作用[3]。Kynuramine (1.25、2.5 和 5.0 mg/kg；静脉注射；单剂量) 可增加髓内大鼠的心率和血压[4]。 Animal Model: |
| Name | Kynuramine dihydrochloride |
| CAS | 36681-58-0 |
| Formula | C9H14Cl2N2O |
| Molar Mass | 237.13 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. J B Massey, et al. Kynuramine, a fluorescent substrate and probe of plasma amine oxidase. J Biol Chem. 1977 Nov 25;252(22):8081-4. [2]. T D Johnson, An alpha-adrenoceptor inhibitory action of kynuramine. Eur J Pharmacol. 1981 Jul 10;72(4):351-6. [3]. S D Mendelson, et al. Intraventricular administration of l-kynurenine and kynuramine facilitates lordosis in the female rat. Eur J Pharmacol. 1987 Oct 27;142(3):447-51. [4]. T D Johnson, et al. Blood pressure and heart rate effects of kynuramine in pithed rats. Eur J Pharmacol. 1983 Feb 18;87(2-3):323-6. |
Kynuramine dihydrochloride
CAS: 36681-58-0 F: C9H14Cl2N2O W: 237.13
Kynuramine, an endogenously occurring amine, is a fluorescent substrate and probe of plasma amine oxidase.
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