Kynuramine dihydrobromide_product_DataBase

Bioactivity	Kynuramine dihydrobromide, an endogenously occurring amine, is a fluorescent substrate of plasma amine oxidase[1][2].
Invitro	Kynuramine dihydrobromide 在体外抑制突触前和突触后 α-肾上腺素受体[2]。Kynuramine dihydrobromide 已被证明是狗脑动脉血清素受体的部分激动剂[2]。Kynuramine dihydrobromide (20 μg/mL) 导致回肠轻微收缩，但未能改变胆碱能刺激的抽搐反应[2]。
In Vivo	Kynuramine dihydrobromide (0.064-8 μg；脑室内；单剂量) 促进雌激素激发的去卵巢大鼠前凸行为[3]。Kynuramine dihydrobromide (1.25-5.0 mg/kg；静脉注射；单剂量) 可增加大鼠的心率和血压[4]。 Animal Model:
Name	Kynuramine dihydrobromide
CAS	304-47-2
Formula	C9H14Br2N2O
Molar Mass	326.03
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. J B Massey, et al. Kynuramine, a fluorescent substrate and probe of plasma amine oxidase. J Biol Chem. 1977 Nov 25;252(22):8081-4. [2]. T D Johnson, An alpha-adrenoceptor inhibitory action of kynuramine. Eur J Pharmacol. 1981 Jul 10;72(4):351-6. [3]. S D Mendelson, et al. Intraventricular administration of l-kynurenine and kynuramine facilitates lordosis in the female rat. Eur J Pharmacol. 1987 Oct 27;142(3):447-51. [4]. T D Johnson, et al. Blood pressure and heart rate effects of kynuramine in pithed rats. Eur J Pharmacol. 1983 Feb 18;87(2-3):323-6.

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