| Bioactivity | Kanglexin is an orally active and novel anthraquinone compound. Kanglexin inhibits NLRP3 inflammatory body activation and cell pyroptosis, and has a cardioprotective effect. Kanglexin promotes angiogenesis through FGFR1/ERK signaling pathway and accelerates diabetic wound healing. In addition, Kanglexin has the effect of lipid-lowering and inhibiting the dedifferentiation of vascular smooth muscle cells, and can be used in the study of hyperlipidemia, fatty liver and atherosclerosis[1][2][3][4]. |
| Invitro | Kanglexin (10-20 μM；24 小时) 可抑制缺氧或 LPS (HY-D1056) 处理的心肌细胞的焦亡[1]。Kanglexin (5-20 μM；24 小时) 在油酸 (HY-N1446) 处理的 HepG2 细胞中通过 AMPK/SREBP-2/PCSK9/LDLR 信号通路降低脂质水平[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Kanglexin 相关抗体: Western Blot Analysis[1] Cell Line: |
| In Vivo | Kanglexin (20-40 mg/kg；灌胃；7 天) 在心肌梗死小鼠模型中具有改善作用[1]。Kanglexin (20-80 mg/kg；口服；2 周) 在高脂血症大鼠模型中具有改善作用[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 2228847-12-7 |
| Formula | C21H18O8 |
| Molar Mass | 398.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bian Y, et al. Kanglexin, a novel anthraquinone compound, protects against myocardial ischemic injury in mice by suppressing NLRP3 and pyroptosis. Acta Pharmacol Sin. 2020 Mar;41(3):319-326. [2]. Li X, et al. Kanglexin, a new anthraquinone compound, attenuates lipid accumulation by activating the AMPK/SREBP-2/PCSK9/LDLR signalling pathway. Biomed Pharmacother. 2021 Jan;133:110802. [3]. Yang S, et al. Kanglexin counters vascular smooth muscle cell dedifferentiation and associated arteriosclerosis through inhibiting PDGFR. Phytomedicine. 2024 Jul 25;130:155704. [4]. Zhao Y, et al. Kanglexin accelerates diabetic wound healing by promoting angiogenesis via FGFR1/ERK signaling. Biomed Pharmacother. 2020 Dec;132:110933. |