| Bioactivity | K145 hydrochloride is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC50 of 4.3 µM and a Ki of 6.4 µM. K145 hydrochloride is inactive against SphK1 and other protein kinases. K145 hydrochloride induces cell apoptosis and has potently antitumor activity[1]. |
| Invitro | K145 (0-10 µM; 24-72 hours; U937 cells) treatment significantly inhibits the growth of U937 cells in a concentration-dependent manner[1].K145 (10 µM; 24 hours; U937 cells) treatment significantly induces apoptosis in U937 cells[1].K145 (4-8 µM; 3 hours; U937 cells) treatment decreases the phosphorylation of ERK and Akt[1].Treatment with K145 (10 µM) causes a decrease of total cellular S1P without significant effects on ceramide levels[1]. Cell Viability Assay[1] Cell Line: |
| Name | K145 hydrochloride |
| CAS | 1449240-68-9 |
| Formula | C18H25ClN2O3S |
| Molar Mass | 384.92 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
K145 hydrochloride
CAS: 1449240-68-9 F: C18H25ClN2O3S W: 384.92
K145 hydrochloride is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC50 of 4.3 µM and a
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