| Bioactivity | JNJ-303 is a specific delayed rectifier Kv blocker. JNJ 303 can potent block IKs with an IC50 value of 64 nM. JNJ-303 can be used for the research of diabetes, obesity and central nervous system[1][2]. | ||||||||||||
| Target | IC50: 64 nM (IKs) | ||||||||||||
| Invitro | JNJ 303 can block IKs with an IC50 value of 64 nM[1]. JNJ 303 (3.3 μM) does not have any effects on other cardiac channels[1].JNJ 303 induces QT-prolongations and causes unprovoked torsades de pointes (TdP)[1]. | ||||||||||||
| In Vivo | JNJ 303 recapitulates the Exn4-induced decrease in fasting blood glucose level in mice[2]. | ||||||||||||
| Name | JNJ 303 | ||||||||||||
| CAS | 878489-28-2 | ||||||||||||
| Formula | C21H29ClN2O4S | ||||||||||||
| Molar Mass | 440.98 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Julie Albrecht, et al. The effect of the KV7/KCNE 1 inhibitor JNJ 303 on heart slices and the L-type calcium channel of cardiac cells. [2]. Zhaohuan Huang, et al. Glucose-sensing glucagon-like peptide-1 receptor neurons in the dorsomedial hypothalamus regulate glucose metabolism. Sci Adv. 2022 Jun 10;8(23):eabn5345. |
JNJ 303
CAS: 878489-28-2 F: C21H29ClN2O4S W: 440.98
JNJ-303 is a specific delayed rectifier Kv blocker. JNJ 303 can potent block IKs with an IC50 value of 64 nM. JNJ-303 ca
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.