| Bioactivity | JJH260 is AIG1inhibitor, and inhibit the fluorophosphonate reactivity and fatty acid esters of hydroxy fatty acid (FAHFA) hydrolysis activity of AIG1in HEK293T cells, with IC50 values of 0.50 μM and 0.57 μM, respectively[1]. |
| Target | 0.50 μM (AIG1) and 0.57 μM (FAHFA) in HEK293T cells |
| Invitro | JJH260 (30 min) 抑制 HEK293T 细胞中的ADTRP, FP-Rh标记的 hAIG1 及其 9-PAHSA 水解活性，IC50 分别为 8.5、0.5 和 0.57 μM[1]。JJH260 (5 μM, 4 h) 抑制 LNCaP 细胞和人 T 细胞的 FAHFA 水解[1]。 |
| Name | JJH260 |
| CAS | 1831135-30-8 |
| Formula | C29H34ClN5O5 |
| Molar Mass | 568.06 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. William H Parsons, et al. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs. Nat Chem Biol. 2016 May;12(5):367-372. [2]. |