Isoangustone A_product_DataBase

Bioactivity	Isoangustone A is an anticancer and anti-inflammatory agent. Isoangustone A induces cancer cells apoptosis and autophagic cell death[1][2][3].
Target	Apoptosis, Autophagy
Invitro	Isoangustone A (10 and 20 μM; 48 and 72 h) 抑制 SK-MEL-28 细胞增殖并诱导 G1 期细胞周期阻滞[1]。Isoangustone A (10 and 20 μM; 48 h) 通过 Akt/GSK3β 和 MKK4/MKK7/JNKs 信号通路介导 G1 期相关蛋白的丰度降低[1]。Isoangustone A 通过 ATP 竞争方式直接结合抑制 PI3-K、MKK4 和 MKK7 激酶活性[1]。Isoangustone A (20 μM; 0.5-4 h) 通过激活 AMPK 信号诱导结直肠癌细胞自噬[2]。Isoangustone A (1-20 μM; 0-100 min) 抑制线粒体呼吸[2]。Isoangustone A (15 μM; 6 h) 诱导 SW480 细胞凋亡[2]。Isoangustone A (1-20 μΜ; 3 days) 抑制人肾系膜细胞的纤维化和炎症[3]。 Cell Proliferation Assay[1] Cell Line:
In Vivo	Isoangustone A (2 or 10 mg/kg; i.p.; daily for 35 days) 显著降低小鼠 SK-MEL-28 异种移植物的肿瘤生长、体积和重量[1]。 Animal Model:
Name	Isoangustone A
CAS	129280-34-8
Formula	C25H26O6
Molar Mass	422.47
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Song NR, et al. Isoangustone A, a novel licorice compound, inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. Cancer Prev Res (Phila). 2013 Dec;6(12):1293-303. [2]. Tang S, et al. Isoangustone A induces autophagic cell death in colorectal cancer cells by activating AMPK signaling. Fitoterapia. 2021 Jul;152:104935. [3]. Li J, et al. Isoangustone A suppresses mesangial fibrosis and inflammation in human renal mesangial cells. Exp Biol Med (Maywood). 2011 Apr 1;236(4):435-44.

PeptideDB

Isoangustone A

CAS: 129280-34-8 F: C25H26O6 W: 422.47