| Bioactivity | Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid), a derivative of Lithocholic acid (HY-10219), is a T cell regulator. Isoallolithocholic acid enhances regulatory T cells (Tregs) differentiation[1]. | ||||||||||||
| Invitro | Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid) (20 μM) reduces Th17 cell differentiation by ~50% without affecting RORγt expression[1].Isoallolithocholic acid does not affect T cell differentiation into Th1 or Th2 cells, the modulatory effect of Isoallolithocholic acid on Tregs is cell-type specific[1].Isoallolithocholic acid-dependent enhanced expression of FoxP3 requires mitoROS[1]. | ||||||||||||
| In Vivo | Isoallolithocholic acid (0.03%; in diet; 7 days) enhances Treg cells in B6 mice[1]. Animal Model: | ||||||||||||
| Name | Isoallolithocholic acid | ||||||||||||
| CAS | 2276-93-9 | ||||||||||||
| Formula | C24H40O3 | ||||||||||||
| Molar Mass | 376.57 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Hang S, et al. Bile acid metabolites control TH17 and Treg cell differentiation. Nature. 2019 Dec;576(7785):143-148. |
Isoallolithocholic acid
CAS: 2276-93-9 F: C24H40O3 W: 376.57
Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid), a derivative of Lithocholic acid (HY-10219), is a T cell regula
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