| Bioactivity | Insulin β Chain Peptide (15-23), also known as INS, is an insulin-derived peptide recognized by islet-associated T cells. The Insulin β Chain Peptide (15-23) tetramer stained the INS-reactive CTL clone G9C8, but neither this tetramer nor the negative control tetramer (TUM) stained the splenic CD8+ T cells from NOD or 8.3-TCRαβtransgenic NOD mice[1][2]. |
| Name | Insulin β Chain Peptide (15-23) |
| CAS | 247044-67-3 |
| Sequence | Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly |
| Shortening | LYLVCGERG |
| Formula | C44H72N12O13S |
| Molar Mass | 1009.18 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Amrani A, et al. Progression of autoimmune diabetes driven by avidity maturation of a T-cell population. Nature. 2000;406(6797):739-742. [2]. Takaki T, et al. Requirement for both H-2Db and H-2Kd for the induction of diabetes by the promiscuous CD8+ T cell clonotype AI4. J Immunol. 2004;173(4):2530-2541. |
Insulin β Chain Peptide (15-23)
CAS: 247044-67-3 F: C44H72N12O13S W: 1009.18
Insulin β Chain Peptide (15-23), also known as INS, is an insulin-derived peptide recognized by islet-associated T cell
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