Indomethacin (GMP)_product_DataBase

Bioactivity	Indomethacin (GMP) is Indomethacin (HY-14397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research[1][2][3].
Invitro	Indomethacin (Indometacin)（0-150 μM；24 小时；3LL-D122 细胞）具有体外抗癌活性[2]。Indomethacin (Indometacin) (0-1000 μM) 通过激活 PKR，导致 eF2α 磷酸化，进而关闭病毒蛋白翻译并抑制病毒复制，保护宿主细胞免受病毒损害 (IC50=2 μM)[3]。Indomethacin (8 μM, 26 h) 诱导 M1 型的 RAW 264.7 细胞向 M2 型分化[4]。Indomethacin (200 μM, 5 天) 诱导人脂肪源性干细胞向神经源样细胞转分化[5]。 0 --> Indomethacin (GMP) 相关抗体:
In Vivo	Indomethacin 可用于动物建模，构建胃肠溃疡模型。Indomethacin（0.01-10 mg/kg；口服；持续 3 小时；雄性 Sprague-Dawley 大鼠）诱导爪水肿和痛觉过敏剂量依赖性逆转角叉菜胶引起的痛觉过敏[1]。Indomethacin (Indometacin)（10 mg/mL；口服；每天一次，持续 29 天；雄性 C57BL/6J 小鼠）可抑制体内肿瘤生长[2]。
Name	Indomethacin (GMP)
CAS	53-86-1
Formula	C19H16ClNO4
Molar Mass	357.79
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Riendeau D, et, al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17. [2]. Eli Y, et, al. Comparative effects of indomethacin on cell proliferation and cell cycle progression in tumor cells grown in vitro and in vivo. Biochem Pharmacol. 2001 Mar 1;61(5):565-71. [3]. Amici C, et, al. Inhibition of viral protein translation by indomethacin in vesicular stomatitis virus infection: role of eIF2α kinase PKR. Cell Microbiol. 2015 Sep;17(9):1391-404. [4]. Luo X, Xiong H, Jiang Y, et al. Macrophage Reprogramming via Targeted ROS Scavenging and COX-2 Downregulation for Alleviating Inflammation. Bioconjug Chem. 2023;34(7):1316-1326. [5]. Kompisch KM, Lange C, Steinemann D, et al. Neurogenic transdifferentiation of human adipose-derived stem cells? A critical protocol reevaluation with special emphasis on cell proliferation and cell cycle alterations. Histochem Cell Biol. 2010;134(5):453-468.

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Indomethacin (GMP)

CAS: 53-86-1 F: C19H16ClNO4 W: 357.79