| Bioactivity | Indapamide-d6 is a deuterated labeled Indapamide[1]. Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy[2][5]. |
| Invitro | 氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Indapamide-d6 相关抗体: |
| In Vivo | Indapamide (1 mg/kg/d; gastric gavage for 8 weeks) lowers blood pressure in spontaneously hypertensive rats (SHRs)[5]. Indapamide (10 mg/kg/d) decreases pressor response to oxotremorine, noradrenaline, and tyramine in rats[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Formula | C17H12D6ClN3O3S |
| Molar Mass | 385.90 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Chaffman, M, et, al. Indapamide. Drugs 28, 189–235 (1984). [3]. Furman BL, et, al. A further examination of the possible effects of indapamide on glucose tolerance and insulin secretion in the rat and mouse. J Pharm Pharmacol. 1981 Nov;33(11):735-7. [4]. Lalande A, et, al. Indapamide, a thiazide-like diuretic, decreases bone resorption in vitro. J Bone Miner Res. 2001 Feb;16(2):361-70. [5]. Ma F, et, al. Indapamide lowers blood pressure by increasing production of epoxyeicosatrienoic acids in the kidney. Mol Pharmacol. 2013 Aug;84(2):286-95. |