| Bioactivity | Imipramine hydrochloride is an orally active tertiary amine tricyclic antidepressant. Imipramine hydrochloride is a Fascin1 inhibitor with antitumor activities. Imipramine hydrochloride also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine hydrochloride stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine hydrochloride shows neuroprotective and immunomodulatory effects[1][2][3][4][5]. |
| Invitro | Imipramine (0.5-300 μM, 3 days) inhibits HCT-116 cell viability[1].Imipramine (20 μM) inhibits cell migration (7 h) and invasion (48 h)[1].Imipramine (50 μM, 0-240 min) inhibites the PI3K/Akt/mTOR signaling pathway in U-87MG glioma cells[2].Imipramine (60 μM, 24 h) stimulates U-87MG glioma cells autophagy[2].Imipramine (80 μM, 24 h) induces HL-60 cell apoptosis[3]. Cell Viability Assay[1] Cell Line: |
| Name | Imipramine hydrochloride |
| CAS | 113-52-0 |
| Formula | C19H25ClN2 |
| Molar Mass | 316.87 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Imipramine hydrochloride
CAS: 113-52-0 F: C19H25ClN2 W: 316.87
Imipramine hydrochloride is an orally active tertiary amine tricyclic antidepressant. Imipramine hydrochloride is a Fasc
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.