| Bioactivity | Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM[1]. Idoxuridine shows anti-orthopoxvirus activity. | ||||||||||||
| Invitro | Idoxuridine (2-10 μM, 72 hours) has the IC50 value of 4.3 μM of antiviral[1]. Cell Proliferation Assay[1] Cell Line: | ||||||||||||
| In Vivo | Idoxuridine (intraperitoneal injection, 50-200 mg/kg, 3 times, 3 hours interval) can stimulate the production of hemolysin plaque-forming cells (HPFC) to sheep red blood cells (SRBC) in C3HeB/FeJ female and male mice and A/J male mice[2]. Animal Model: | ||||||||||||
| Name | Idoxuridine | ||||||||||||
| CAS | 54-42-2 | ||||||||||||
| Formula | C9H11IN2O5 | ||||||||||||
| Molar Mass | 354.10 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. David J Maggs, et al. In vitro efficacy of ganciclovir, cidofovir, penciclovir, foscarnet, idoxuridine, and acyclovir against feline herpesvirus type-1. Am J Vet Res. 2004 Apr;65(4):399-403. [2]. D E Griswold, et al. Stimulation of hemolysin plaque-forming cells by idoxuridine. Cancer Res. 1975 Jan;35(1):88-92. [3]. Mark N Prichard, et al. Orthopoxvirus targets for the development of antiviral therapies. Curr Drug Targets Infect Disord |