ISX-9 (GMP)_product_DataBase

Bioactivity	ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation. ISX-9 activates Ca2+ influx through both voltage-gated Ca2+ channels and NMDA receptors and increases neuroD expression. ISX-9 also induces cardiomyogenic differentiation of Notch-activated epicardium-derived cells (NECs)[1][2][3].In Vitro: ISX-9 promotes neurogenesis in vivo, enhancing the proliferation and differentiation of hippocampal subgranular zone (SGZ) neuroblasts, and the dendritic arborization of adult-generated dentate gyrus neurons. At 2.5-20 μM, ISX-9 has been shown to dose-dependently trigger neurogenesis and block gliogenesis in adult rat hippocampal stem cells through a calcium-activated signaling pathway dependent on myocyte-enhancer factor 2-dependent gene expression[1].Molecular exploration of ISX-9-induced regulation of neurogenesis (via FACS and microarray of SGZ stem and progenitor cells) suggested the involvement of the myocyte-enhancer family of proteins (Mef2)[1].In Vivo: ISX-9 (20 mg/kg; for 12 days; mice) treatment improves hippocampal function. ISX-9 enhances spatial memory ability in the Morris water maze test. ISX-9 enhances hippocampal neurogenesis and memory in vivo, and its effects are reliant on Mef2[1].
Invitro	ISX-9 ISX-9 (20 μM; 持续 7 天) 可以从人诱导多能干细胞 (hiPSCs) 开始诱导生成心脏祖细胞 (CPCs)[1]。ISX-9 (20 μM)诱导心脏祖细胞 (CPCs) 分泌细胞外囊泡 (EV)[1]。 Western Blot Analysis[1] Cell Line:
In Vivo	CPCISX-9 衍生的 EV 逆转了梗死小鼠的心脏重构[1]。 Animal Model:
Name	ISX-9 (GMP)
CAS	832115-62-5
Formula	C11H10N2O2S
Molar Mass	234.27
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wanling Xuan, et al. miRNAs in Extracellular Vesicles from iPS-Derived Cardiac Progenitor Cells Effectively Reduce Fibrosis and Promote Angiogenesis in Infarcted Heart. Stem Cells Int. 2019 Nov 11;2019:3726392. doi: 10.1155/2019/3726392. eCollection 2019. [2]. Maria Magdalena Barreca, et al. Mesenchymal and Induced Pluripotent Stem Cells-Derived Extracellular Vesicles: The New Frontier for Regenerative Medicine? Cells. 2020 May 8;9(5):1163.

PeptideDB

ISX-9 (GMP)

CAS: 832115-62-5 F: C11H10N2O2S W: 234.27