| Bioactivity | IR-990 is an activatable NIR-II fluorescent probe with an acceptor-π-acceptor (A-π-A) skeleton for real-time detection of H2O2 in vivo. IR-990 is a powerful diagnosis of drug-induced liver injury (DILI)[1]. |
| Invitro | IR-990 (0-30 μM) treatment shows high cell viability[1].IR-990 (10 μM; 1 h) can sensitively visualize endogenous H2O2 levels in cells, and possess excellent ability to detect H2O2 in the cell model of acetaminophen-induced liver injury[1]. Cell Cytotoxicity Assay[1] Cell Line: |
| In Vivo | IR-990 (intravenous injection; 195.31 μg per mouse; once) is a powerful tool for real-time detection of H2O2[1]. Animal Model: |
| Name | IR-990 |
| Formula | C49H47BI2N2O3 |
| Molar Mass | 976.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yang Tian, et al. H2O2-Activated NIR-II Fluorescent Probe with a Large Stokes Shift for High-Contrast Imaging in Drug-Induced Liver Injury Mice. Anal Chem. 2022 Aug 16;94(32):11321-11328. |