| Bioactivity | IP7e is a potent, brain-penetrant and orally active Nurr1 activator with an EC50 value of 3.9 nM[1]. | ||||||||||||
| Target | EC50: 3.9 nM (Nurr1) | ||||||||||||
| In Vivo | IP7e (Isoxazolo-pyridinone 7e; 10 mg/kg; oral gavage; twice a day) preventive treatment reduces the incidence and the severity of a MS murine model, i.e. experimental autoimmune encephalomyelitis (EAE). IP7e attenuates inflammation and neurodegeneration in spinal cords of EAE mice by an NF-kB pathway-dependent process[2]. Animal Model: | ||||||||||||
| Name | IP7e | ||||||||||||
| CAS | 500164-74-9 | ||||||||||||
| Formula | C23H22N2O4 | ||||||||||||
| Molar Mass | 390.43 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Samuel Hintermann, et al. Identification of a series of highly potent activators of the Nurr1 signaling pathway. Bioorg Med Chem Lett. 2007 Jan 1;17(1):193-6. [2]. Francesca Montarolo, et al. Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice. PLoS One. 2014 Sep 29;9(9):e108791. |