| Bioactivity | INT-777 (R-enantiomer) is the R-enantiomer of INT-777, with EC50 of 4.79 μM for TGR5, and less potent than INT-777. | ||||||||||||
| In Vivo | INT-777 (R-enantiomer) is more choleretic than CA (4), but less than INT-777[1]. | ||||||||||||
| Name | INT-777 R-enantiomer | ||||||||||||
| CAS | 1198786-98-9 | ||||||||||||
| Formula | C27H46O5 | ||||||||||||
| Molar Mass | 450.65 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Pellicciari R, et al. Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. J Med Chem. 2009 Dec 24;52(24):7958-61. |
INT-777 R-enantiomer
CAS: 1198786-98-9 F: C27H46O5 W: 450.65
INT-777 (R-enantiomer) is the R-enantiomer of INT-777, with EC50 of 4.79 μM for TGR5, and less potent than INT-777.
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