| Bioactivity | INO5042, a thiazole fused 1,4-naphthoquinone compound, and exhibits anti-inflammation activity[1][2]. | ||||||||||||
| Invitro | When INO5042 is added to endothelial cells, a shift of velocities is observed towards fast speeds (from 3-5 to 7-11 microm/sec). The same results is significantly found when neutrophils, alone or along with endothelium, has been submitted to INO5042, the number of stickers and rollers being reduced as well[1]. | ||||||||||||
| Name | INO5042 | ||||||||||||
| CAS | 14782-19-5 | ||||||||||||
| Formula | C15H7NO3S | ||||||||||||
| Molar Mass | 281.29 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Renard M, et al. Induced changes of leukocyte slow rolling in an in flow pharmacological model of adhesion to endothelial cells. Biorheology. 2003;40(1-3):173-8. [2]. Fosse C, et, al. Parameters and mechanistic studies on the oxidative ring cleavage of synthetic heterocyclic naphthoquinones by Streptomyces strains. Appl Microbiol Biotechnol. 2004 Sep;65(4):446-56. |