| Bioactivity | Human enteropeptidase-IN-2 (compound 1c) is a highly potent enteropeptidase inhibitor. Human enteropeptidase-IN-2 can be used for anti-obesity research[1]. |
| Target | IC50(initial): 540 nM (enteropeptidase)IC50(app): 30 nM (enteropeptidase) |
| Invitro | Human enteropeptidase-IN-2 (compound 1c) has inhibitory activity against enteropeptidase with IC50(initial)* of 540 nM and IC50(app)** of 30 nM[1].(*IC50(initial) refers to the inhibitory activity of human enteropeptidase after 6 min of incubation with the enzyme, substrate, and compound.**IC50(app) refers to the apparent IC50 value after 120 min of incubation with the enzyme, substrate, and compound.) |
| Name | Human enteropeptidase-IN-2 |
| Formula | C20H19F3N4O7 |
| Molar Mass | 484.38 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ikeda Z, et al. Design, Synthesis, and Biological Evaluation of a Novel Series of 4-Guanidinobenzoate Derivatives as Enteropeptidase Inhibitors with Low Systemic Exposure for the Treatment of Obesity. J Med Chem. 2022 Jun 23;65(12):8456-8477. |
Human enteropeptidase-IN-2
CAS: F: C20H19F3N4O7 W: 484.38
Human enteropeptidase-IN-2 (compound 1c) is a highly potent enteropeptidase inhibitor. Human enteropeptidase-IN-2 can be
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