| Bioactivity | Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC50s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation[1][2][3][4]. |
| Invitro | Homobutein (compound 15) (20, 24, 28, 32, 40 μM; 2 h) inhibits the viability of K562 cells[1].Homobutein (2 h) inhibits TNFα-induced NF-κB activity in K562 cells[1].Homobutein (1 μg/mL; 72 h) inhibits the growth of Toxoplasma gondii by 19.48%[2].Homobutein (24 h) againsts W2 and D6 strains of P.falciparum with IC50s of 15.0 and 16.1 µM, respectively[3]. Cell Viability Assay[1] Cell Line: |
| Name | Homobutein |
| CAS | 34000-39-0 |
| Formula | C16H14O5 |
| Molar Mass | 286.28 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |